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VARIABLE REGION, IG
Descriptors Found:
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DeCS
Descriptor
English
:
Immunoglobulin Variable Region
Descriptor
Spanish
:
Región Variable de Inmunoglobulina
Descriptor
Portuguese
:
Região Variável de Imunoglobulina
Synonyms
English
:
Variable Region, Ig
Variable Region, Immunoglobulin
Tree Number:
D12.776.124.486.485.680.650.500
D12.776.124.486.485.797
D12.776.124.790.651.680.650.500
D12.776.124.790.651.797
D12.776.377.715.548.680.650.500
D12.776.377.715.548.797
G06.184.603.060.425
Definition
English
:
That region of the immunoglobulin molecule that varies in its
amino acid sequence
and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Indexing Annotation
English
:
DF: IG VARIABLE REGION
Pharmacological Action:
Immunologic Factors
See Related
English
:
Binding Sites, Antibody
History Note
English
:
84(77); was see under BINDING SITES, ANTIBODY 1977-83
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22209
Unique Identifier:
D007135
Occurrence in VHL
:
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